About

Alternative splicing patterns are unique in the brains of autistic people. Is this pattern a cause or consequence of the disorder? We could get some clues to solving this mystery from the phenotypes of spliceosome-related genetic mutations. Individuals with such mutations often present with neurodevelopmental disorders in general and autism spectrum disorder in particular. We hypothesize that altered pre-mRNA splicing is a cause of autism spectrum disorder and use high-throughput tools to study this connection. 

 

Salton Lab

We use molecular biology techniques and high-throughput sequencing to reveal the layers of pre-mRNS splicing regulation in health and disease. Specifically, we study how chromatin interacts with the spliceosome to alter alternative splicing patterns.

Website design by Yarden Salton-Morgenstern

 
Team Members

Aveksha Sharma

Nadeen Taqatqa

MSc Student

nadeen.taqatqa at huji.mail.ac.il

Tamar Guedj

Undergrad Student

tamar.gueaj at huji.mail.ac.il

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Gillian Kay

Eden Engal

Ophir Geminder

MD Student

ophir.geminder at huji.mail.ac.il

Mai Baker

Mercedes Bentata

Or Ribak

MD Student

or.ribak at huji.mail.ac.il

Alumni
Ahmad Siam, Klil Cohen, Rauf Najar, Yehudit Harush, Sara Dahan, Mayra Petasny 

Lynn Zamechek

 Summer Intern 2017

Special volunteer from the "Israel experience" project.

 
Lab Events
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Selected publications

Sara Dahan, Klil Cohen, Mercedes Bentata, Eden Engal, Ahmad Siam, Gillian Kay, Yotam Drier, Shlomo Elias and Maayan Salton. VEGFA’s distal enhancer regulates its alternative splicing in CML. Accepted for publication in NAR Cancer.

Mayra Petasny, Mercedes Bentata, Andrea Pawellek, Mai Baker, Gillian Kay and Maayan Salton (2020). Splicing To Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle. Trends in Genetics. 2021 Mar;37(3):266-278. Review

Mercedes Bentata, Guy Morgenstern, Yuval Nevo, Gillian Kay, Avital Granit Mizrahi, Mark Temper, Ofra Maimon, Liza Monas, Reham Basheer, Asa Ben-Hur, Tamar Peretz and Maayan Salton. Splicing Factor Transcript Abundance in Saliva as a Diagnostic Tool for Breast Cancer. Genes, 2020, 11(8), 880.

Roni Ben-Ami, ... Yuval Dor*, Dana G Wolf*,  Maayan Salton*,  Yotam Drier*, The Hebrew University-Hadassah COVID-19 diagnosis team. Large-scale implementation of pooled RNA extraction and RT-PCR for SARS-CoV-2 detection.Clinical Microbiology and Infection, 2020, 26 (9), 1248-1253.

Mai Baker, Mayra Petasny, Mercedes Bentata, Gillian Kay, Eden Engal, Yuval Nevo, Ahmad Siam, Sara Dahan, Maayan Salton. KDM3A regulates alternative splicing of cell-cycle genes following DNA damage. bioRxiv 2020.02.26.965970; doi: https://doi.org/10.1101/2020.02.26.965970, 2020.

Ahmad Siam, Mai Baker, Leah Amit, Gal Regev, Alona Rabner, Rauf Ahmad Najar, Mercedes Bentata, Sara Dahan, Klil Cohen, Sarah Araten, Yuval Nevo, Gillian Kay, Yael Mandel-Gutfreund and Maayan Salton. Regulation of alternative splicing by p300-mediated acetylation of splicing factors. RNA, 2019, 25(7), 813-824.

Maayan Salton, Wojciech K. Kasprzak, Ty Voss, Bruce A. Shapiro, Poulikos I. Poulikakos and Tom Misteli. Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicingNature Communications, 2015;6:7103.

Maayan Salton, Ty C. Voss and Tom Misteli. Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing. Nucleic Acids Research, 2014;42(22):13662-73.

Maayan Salton, Yaniv Lerenthal, Shih-Ya Wang, David J. Chen and Yossi Shiloh. Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle, 2010;9(8):1568-76.

 

Introduction to General Genetics (94627)

Under-Graduate Course

The aim of the course is to provide students basic knowledge in genetics of microorganisms (prokaryotes) and creatures with nucleus (eukaryotes), that will serve as a basis for future studies.

Human Genetics
(94622)

Under-Graduate Course

The course covers human hereditary and molecular genetics, with a strong genomics and human disease perspective. My part in the course focuses on epigenetic inheritance, the history of crispr and pre-mRNA splicing and disease.

Presentation skills (94604)

Graduate Course

Nothing paralyses students more than having to present at a conference. It is a scary task, but a scientific career depends on how well we talk in public. Fortunately, improving your presentation skills is possible. The course is built to help reduce your anxiety, to teach you how to build an effective presentation and to improve your performance skills. 

Contact Us
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A main focus of our lab is to train the next generation of scientists. We have created an environment that promotes learning and personal growth in a collaborative and supportive atmosphere. If you are self-motivated and looking for a nurturing lab to grow in contact us.

Teaching

Lectures & Workshops

View from the campus cafeteria by Sarah Araten