We study the epigenetic regulation of pre-mRNA splicing. We use molecular biology techniques and high-throughput sequencing to uncover the layers of alternative splicing regulation.
Website design by Yarden Salton-Morgenstern
Modifications of chromatin structure are known to occur following changes in cellular environment and as an adaptation to altered physiological conditions. In our lab we seek to broaden the understanding of cellular plasticity by studying the regulatory mechanisms of alternative pre-mRNA splicing in physiological and pathological contexts. We wish to pin point the impact of alternative splicing regulation in response to a modified chromatin environment and to understand what part of the cellular response to the physiological cue is mediated by alternative splicing.
Ahmad Siam, Klil Cohen, Rauf Najar, Yehudit Harush
Summer Intern 2017
Special volunteer from the "Israel experience" project.
Lab hike 2017
Ahmad Siam, Mai Baker, Leah Amit, Gal Regev, Alona Rabner, Rauf Ahmad Najar, Mercedes Bentata, Sara Dahan, Klil Cohen, Sarah Araten, Yuval Nevo, Gillian Kay, Yael Mandel-Gutfreund and Maayan Salton. *. Regulation of alternative splicing by p300-mediated acetylation of splicing factors. RNA, 2019
Juste Wesche, Sarah Kühn, Benedikt M. Kessler, Maayan Salton and Alexander Wolf. Protein arginine methylation: a prominent modification and its demethylation. Cell Mol Life Sci, 20172017 Mar 31; 1-11.
Maayan Salton, and Tom Misteli. Small molecule modulators of pre-mRNA splicing in cancer therapy. Trends in Molecular Medicine, 2016 Jan 22; 28-37.
Maayan Salton, Wojciech K. Kasprzak, Ty Voss, Bruce A. Shapiro, Poulikos I. Poulikakos and Tom Misteli. Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing. Nature Communications, 2015 May 14;6:7103.
Maayan Salton, Ty C. Voss and Tom Misteli. Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing. Nucleic Acids Research, 2014 Dec 16;42(22):13662-73. *Corresponding authors
Maayan Salton, Yaniv Lerenthal, Shih-Ya Wang, David J. Chen and Yossi Shiloh. Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle, 2010 Apr 15;9(8):1568-76.
Introduction to General Genetics (94627)
The aim of the course is to provide students basic knowledge in genetics of microorganisms (prokaryotes) and creatures with nucleus (eukaryotes), that will serve as a basis for future studies.
The course covers human hereditary and molecular genetics, with a strong genomics and human disease perspective. My part in the course focuses on epigenetic inheritance, the history of crispr and pre-mRNA splicing and disease.
Presentation skills (94604)
Nothing paralyses students more than having to present at a conference. It is a scary task, but a scientific career depends on how well we talk in public. Fortunately, improving your presentation skills is possible. The course is built to help reduce your anxiety, to teach you how to build an effective presentation and to improve your performance skills.
Lectures & Workshops
View from the campus cafeteria by Sarah Araten