About

Modifications of chromatin structure are known to occur following changes in cellular environment and as an adaptation to altered physiological conditions. In our lab we seek to broaden the understanding of cellular plasticity by studying the regulatory mechanisms of alternative pre-mRNA splicing in physiological and pathological contexts. We wish to pin point the impact of alternative splicing regulation in response to a modified chromatin environment and to understand what part of the cellular response to the physiological cue is mediated by alternative splicing.

 

Salton Lab

We study the epigenetic regulation of pre-mRNA splicing. We use molecular biology techniques and high-throughput sequencing to uncover the layers of alternative splicing regulation.

Website design by Yarden Salton-Morgenstern

 
Team Members

Aveksha Sharma

Sara Dahan

Heba Ombashe

Undergrad Student

heba.ombashe at huji.mail.ac.il

Gillian Kay

Eden Engal

Mayra Petasny

Ophir Geminder

MD Student

ophir.geminder at huji.mail.ac.il

Mai Baker

Mercedes Bentata

Nadeen Taqatqa

MSc Student

nadeen.taqatqa at huji.mail.ac.il

Alumni
Ahmad Siam, Klil Cohen, Rauf Najar, Yehudit Harush 

Lynn Zamechek

 Summer Intern 2017

Special volunteer from the "Israel experience" project.

 
Lab Events
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Lab hike 2017

 
Selected publications

Mercedes Bentata, Guy Morgenstern, Yuval Nevo, Gillian Kay, Avital Granit Mizrahi, Mark Temper, Ofra Maimon, Liza Monas, Reham Basheer, Asa Ben-Hur, Tamar Peretz and Maayan Salton. Splicing Factor Transcript Abundance in Saliva as a Diagnostic Tool for Breast Cancer. Genes, 2020, 11(8), 880.

Roni Ben-Ami, Agnes Klochendler, Matan Seidel, Tal Sido, Ori Gurel-Gurevich, Moran Yassour,  Eran Meshorer, Gil Benedek, Irit Fogel,  Esther Oiknine-Djian, Asaf Gertler, Zeev Rotstein, Bruno Lavi, Yuval Dor*, Dana G Wolf*,  Maayan Salton*,  Yotam Drier*, The Hebrew University-Hadassah COVID-19 diagnosis team. Clinical Microbiology and Infection, 2020, 26 (9), 1248-1253.

Mai Baker, Mayra Petasny, Mercedes Bentata, Gillian Kay, Eden Engal, Yuval Nevo, Ahmad Siam, Sara Dahan, Maayan Salton. KDM3A regulates alternative splicing of cell-cycle genes following DNA damage. bioRxiv 2020.02.26.965970; doi: https://doi.org/10.1101/2020.02.26.965970, 2020.

Ahmad Siam, Mai Baker, Leah Amit, Gal Regev, Alona Rabner, Rauf Ahmad Najar, Mercedes Bentata, Sara Dahan, Klil Cohen, Sarah Araten, Yuval Nevo, Gillian Kay, Yael Mandel-Gutfreund and Maayan Salton. Regulation of alternative splicing by p300-mediated acetylation of splicing factors. RNA, 2019, 25(7), 813-824.

Maayan Salton, and Tom Misteli. Small molecule modulators of pre-mRNA splicing in cancer therapy. Trends in Molecular Medicine, 2016 Jan 22; 28-37.

Maayan Salton, Wojciech K. Kasprzak, Ty Voss, Bruce A. Shapiro, Poulikos I. Poulikakos and Tom Misteli. Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing. Nature Communications, 2015;6:7103.

Maayan Salton, Ty C. Voss and Tom Misteli. Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing. Nucleic Acids Research, 2014;42(22):13662-73.

Maayan Salton, Yaniv Lerenthal, Shih-Ya Wang, David J. Chen and Yossi Shiloh. Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle, 2010;9(8):1568-76.

 

Introduction to General Genetics (94627)

Under-Graduate Course

The aim of the course is to provide students basic knowledge in genetics of microorganisms (prokaryotes) and creatures with nucleus (eukaryotes), that will serve as a basis for future studies.

Human Genetics
(94622)

Under-Graduate Course

The course covers human hereditary and molecular genetics, with a strong genomics and human disease perspective. My part in the course focuses on epigenetic inheritance, the history of crispr and pre-mRNA splicing and disease.

Presentation skills (94604)

Graduate Course

Nothing paralyses students more than having to present at a conference. It is a scary task, but a scientific career depends on how well we talk in public. Fortunately, improving your presentation skills is possible. The course is built to help reduce your anxiety, to teach you how to build an effective presentation and to improve your performance skills. 

Contact Us

A main focus of our lab is to train the next generation of scientists. We have created an environment that promotes learning and personal growth in a collaborative and supportive atmosphere. If you are self-motivated and looking for a nurturing lab to grow in contact us.

Teaching

Lectures & Workshops

View from the campus cafeteria by Sarah Araten 

Address

Biochemistry and Molecular Biology Department
The Institute for Medical Research Israel-Canada 
The Hebrew University Faculty of Medicine
Address: Botnar bldg., Entrance floor, Room Lab:  002 office: 023
Ein Karem, 91120, Jerusalem, Israel

maayan.salton at mail.huji.ac.il

+972-2-6758814

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