Modifications of chromatin structure are known to occur following changes in cellular environment and as an adaptation to altered physiological conditions. In our lab we seek to broaden the understanding of cellular plasticity by studying the regulatory mechanisms of alternative pre-mRNA splicing in physiological and pathological contexts. We wish to pin point the impact of alternative splicing regulation in response to a modified chromatin environment and to understand what part of the cellular response to the physiological cue is mediated by alternative splicing.
We study the epigenetic regulation of pre-mRNA splicing. We use molecular biology techniques and high-throughput sequencing to uncover the layers of alternative splicing regulation.
Website design by Yarden Salton-Morgenstern
Ahmad Siam, Klil Cohen, Rauf Najar, Yehudit Harush
Summer Intern 2017
Special volunteer from the "Israel experience" project.
Mercedes Bentata, Guy Morgenstern, Yuval Nevo, Gillian Kay, Avital Granit Mizrahi, Mark Temper, Ofra Maimon, Liza Monas, Reham Basheer, Asa Ben-Hur, Tamar Peretz and Maayan Salton. Splicing Factor Transcript Abundance in Saliva as a Diagnostic Tool for Breast Cancer. Genes, 2020, 11(8), 880.
Roni Ben-Ami, Agnes Klochendler, Matan Seidel, Tal Sido, Ori Gurel-Gurevich, Moran Yassour, Eran Meshorer, Gil Benedek, Irit Fogel, Esther Oiknine-Djian, Asaf Gertler, Zeev Rotstein, Bruno Lavi, Yuval Dor*, Dana G Wolf*, Maayan Salton*, Yotam Drier*, The Hebrew University-Hadassah COVID-19 diagnosis team. Clinical Microbiology and Infection, 2020, 26 (9), 1248-1253.
Mai Baker, Mayra Petasny, Mercedes Bentata, Gillian Kay, Eden Engal, Yuval Nevo, Ahmad Siam, Sara Dahan, Maayan Salton. KDM3A regulates alternative splicing of cell-cycle genes following DNA damage. bioRxiv 2020.02.26.965970; doi: 2020.
Ahmad Siam, Mai Baker, Leah Amit, Gal Regev, Alona Rabner, Rauf Ahmad Najar, Mercedes Bentata, Sara Dahan, Klil Cohen, Sarah Araten, Yuval Nevo, Gillian Kay, Yael Mandel-Gutfreund and Maayan Salton. Regulation of alternative splicing by p300-mediated acetylation of splicing factors. RNA, 2019, 25(7), 813-824.
Maayan Salton, and Tom Misteli. Small molecule modulators of pre-mRNA splicing in cancer therapy. Trends in Molecular Medicine, 2016 Jan 22; 28-37.
Maayan Salton, Wojciech K. Kasprzak, Ty Voss, Bruce A. Shapiro, Poulikos I. Poulikakos and Tom Misteli. Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing. Nature Communications, 2015;6:7103.
Maayan Salton, Ty C. Voss and Tom Misteli. Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing. Nucleic Acids Research, 2014;42(22):13662-73.
Maayan Salton, Yaniv Lerenthal, Shih-Ya Wang, David J. Chen and Yossi Shiloh. Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle, 2010;9(8):1568-76.